Supercomputer HPC: Applications

Termiczna ablacja materiałów biologicznych za pomocą nanocząstek złota

Identyfikator grantu: PT00899

Kierownik projektu: Piotr Radomski

Politechnika Gdańska

Wydział Inżynierii Mechanicznej i Okrętownictwa

Gdańsk

Data otwarcia: 2021-09-22

Streszczenie projektu

Celem projektu jest znalezienie odpowiedniego rozmiaru i kształtu nanocząstek złota do ich ablacji w zależności od długości fali i ośrodka, w którym są umieszczone do uzyskania największego przegrzania bakterii, wirusów czy guzów punktowych przy jednoczesnym niezniszczeniu zdrowych komórek.

Projekt ma być rozwijany od teorii i symulacji przy użyciu skomplikowanej fizyki, przez liczne doświadczenia, aż po ewentualne wdrożenie i badania kliniczne do ich rzeczywistego zastosowania. Owocem projektu ma być opracowanie nowej nieinwazyjnej metody niszczenia guzów bez operacji chirurgicznych, usuwanie bakterii z wody bez użycia filtrów czy dezaktywacja różnego typu wirusów.

Publikacje

  1. Radomski et al., Effects of the laser-ablated metallic nanoparticles shapes on the photo-thermal performances in a selected fluidic medium. 15th Mediterranean Workshop and Topical Meeting, 15th Mediterranean Workshop and Topical Meeting "Novel Optical Materials and Applications”, University of Calabria, Cetraro (Italy) -, (2022) -
  2. Radomski P. et al., Theoretical approach of laser-irradiated metallic nanoparticles in selected mixedconvection systems, Conference monograph of XVI Heat and Mass Transfer Symposium in Mragowo -, (2022) -
  3. Federica Zaccagnini, Piotr Radomski, Maria Laura Sforza, Paweł Ziółkowski, Seok-In Lim, Kwang-Un Jeong, Dariusz Mikielewicz, Nicholas P. Godman, Dean R. Evans, Jonathan E. Slagle, Michael E. McConney, Daniela De Biase, Francesca Petronella, Luciano De Sio, White light thermoplasmonic activated gold nanorod arrays enable the photo-thermal disinfection of medical tools from bacterial contamination, Journal of Materials Chemistry B 11, (2023) 6823–6836
  4. Piotr Radomski, Paweł Ziółkowski, Dariusz Mikielewicz, Energy Conversion in Systems-Contained Laser-Irradiated Metallic Nanoparticles – Comparison of Results from Analytical Solutions and Numerical Methods, Acta Mechanica et Automatica 17(4), (2023) 540-549
  5. Piotr Radomski, Federica Zaccagnini, Paweł Ziółkowski, Francesca Petronella, Luciano De Sio, Dariusz Mikielewicz, Heat Transfer of the Multicolor-Laser-Sources-Irradiated Nanoparticles in Reference to Thermal Processes, PROCEEDINGS OF ECOS 2023 - THE 36TH INTERNATIONAL CONFERENCE ON EFFICIENCY, COST, OPTIMIZATION, SIMULATION AND ENVIRONMENTAL IMPACT OF ENERGY SYSTEMS 25-30 JUNE, 2023, LAS PALMAS DE GRAN CANARIA, SPAIN 1, (2023) 356-367
  6. Aimad Koulali, Paweł Ziółkowski, Piotr Radomski, Luciano De Sio, Jacek Zieliński, Dariusz Mikielewicz, Single-phase CFD approach for investigating bacterial inactivation and heat transfer in a microchamber, Book of Extended Abstracts (Książka referatów), Journal of Politechnika Gdańska, XXV Jubilee Congress of Thermodynamics, September 11th – 14th, 2023, Gdańsk-Sobieszewo, Poland 1, (2023) 167-170
  7. Piotr Radomski, Paweł Ziółkowski, Luciano De sio, Dariusz Mikielewicz, Studies on light-ablated noble metallic nanoparticles in a flow pipe in reference to energy and biomedical performances, XV Workshop Muliphase Flows & Summer School Multiphase Flows, June 13th – 15th, 2023, Grabówko, Poland 1, (2023) 1
  8. Piotr Radomski, Paweł Ziółkowski, Luciano De Sio, Dariusz Mikielewicz, Theoretical approach of electromagnetic energy convertion into useful heat via different types of light source. Determination of absorbed energy, Biophotonics at the nanoscale: from smart nanomaterials to advanced optical technologies for life, environmental science and nanomedicine 1, (2023) 1
  9. Piotr Radomski, Paweł Ziółkowski, Luciano De sio, Dariusz Mikielewicz, Theoretical approach of electromagnetic energy convertion into useful heat via different types of light source. Source implementation into CFD numerical methods, Biophotonics at the nanoscale: from smart nanomaterials to advanced optical technologies for life, environmental science and nanomedicine 1, (2023) 1
  10. Paweł Ziółkowski, Jacek Zieliński, Piotr Radomski, Luciano De Sio, Francesca Petronella, Federica Zaccagnini, Dariusz Mikielewicz, Selected aspects of thermodynamics in cancer therapy, XXV Jubilee Congress of Thermodynamics, 167-170, September 11th – 14th, 2023, Gdańsk-Sobieszewo, Poland 1, (2023) 1
  11. Piotr Radomski, Paweł Ziółkowski, Dariusz Mikielewicz, Analysis of heat transfer processes in the germicidal chamber subjected to light illumination, XXV Jubilee Congress of Thermodynamics, 167-170, September 11th – 14th, 2023, Gdańsk-Sobieszewo, Poland 1, (2023) 1
  12. Piotr Radomski, Paweł Ziółkowski, Luciano De Sio, Dariusz Mikielewicz, Heat transfer in a metallic-nanoparticles-contained system using the discrete-ordinates and thin-film-asjusted models, XXV Jubilee Congress of Thermodynamics, 167-170, September 11th – 14th, 2023, Gdańsk-Sobieszewo, Poland 1, (2023) 1
  13. Paweł Ziółkowski, Aimad Koulali, Piotr Radomski, Luciano De Sio, Analyses of power laser impact on inactivation of Escherichia coli by using Computation Fluid Dynamics with single-phase approach, NATO - ADVANCED RESEARCH WORKSHOP 1, (2023) 1
  14. Radomski Piotr, Ziółkowski Paweł, Zaccagnini Federica, Koulali Aimad, Petronella Francesca, De Sio Luciano, Zieliński Jacek, Mikielewicz Dariusz, Modelling of light energy conversion into heat in systems containing metallic nanoparticles, Projects reports, Insitute of Energy, July 20th – 25th, 2023, Gdańsk, Poland 1, (2023) 1
  15. Aimad Koulali, Paweł Ziółkowski, Piotr Radomski, Luciano De Sio, Jacek Zieliński, Dariusz Mikielewicz, Laser-assisted thermal inactivation of Escherichia Coli in a microfluidic chamber—CFD simulation and Arrhenius equation analysis, Projects reports, Insitute of Energy, July 20th – 25th, 2023, Gdańsk, Poland 1, (2023) 1
  16. Aimad Koulali, Paweł Ziółkowski, Piotr Radomski, Luciano De Sio, Jacek Zieliński, Dariusz Mikielewicz, Analysis of heat transfer and AuNPs-mediated photo-thermal inactivation of E. coli at varying laser powers using single-phase CFD modeling, Archives of Thermodynamics 45, (2024) 1
  17. P. Ziółkowski, A. Koulali, P. Radomski, D. De Biase, F. Zaccagnini, J. Zieliński, M. Pikuła, K. Jeong, F. Petronella, L. De Sio, D. Mikielewicz, BACTERIAL INACTIVATION VIA LASER-DRIVEN GOLD NANOPARTICLE HEATING: SIMULATION AND ANALYSIS, 9th Thermal and Fluids Engineering Conference (TFEC) April, 21-24, 2024 Partially Online Virtual and at Oregon State University, OR 1, (2024) 1-12
  18. A. Koulali, P. Radomski, L. De Sio, D. Mikielewicz, P. Ziółkowski , CFD COUPLING OF VOF MODEL WITH ARRHENIUS EQUATION FOR ANALYSIS OF LASER-INDUCED THERMAL DEACTIVATION OF E. COLI, 9th Thermal and Fluids Engineering Conference (TFEC) April, 21-24, 2024 Partially Online Virtual and at Oregon State University, OR 1, (2024) 1-13

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