TASK Quarterly   Scientific Bulletin of the Centre of Informatics - Tricity Academic Supercomputer & networK   ISSN 1428-6394

    2/97 "Informatics in Medicine"

    Guest editor: prof. A. Nowakowski, antowak@sunrise.pg.gda.pl
    Technical University of Gdansk, Poland



    Contents:

    • J.Ruminski, A.Nowakowski, Advances of Medical Visualisation - abstract
    • R.Deklerck, A.Salomie, J.Cornelis, An Editor for 3D Medical Volume Images - abstract
    • M.Kocikowski, A.Polinski, A.Nowakowski, J.Wtorek, Problems of 3D reconstruction and visualisation in EIT - abstract
    • D.Kozinska, K.Nowinski, A.Kolodziejak, R.Tarnecki, Integration of EEG and MRI data of Individual Brain - abstract
    • R.J.Barczynski, A.Kubasik, Nonlinear Methods in Heart Rate Variability - abstract
    • R.Kalicka, Optimal Multicompartmental Experiment Design - abstract
    • R. Pawlowski, Population Genetics of the Amplified Fragment Length Polymorphism (AMPFL) and Short Tandem Repeat (STR) Type Systems in the Population of Northern Poland (Gdansk Area) - abstract
    • J.Furmanski, R.Szczech, L.Znaniecki, M.Wroczynski, Brief Guide to Medical Internet - abstract

    From the History of Science and Technology in Ancient Gdansk

    ABSTRACTS:

  • J.Rumiñski, A.Nowakowski, Advances of medical visualisation
    In the paper the review of most commonly used techniques of medical visualisation is presented. Both 2D and 3D medical visualisation problems are illustrated with examples of our research. Especially remote visualisation (teleradiology) with telematics tools is taken into consideration. This leads to underline the role of networking in telediagnosis. The importance of application of powerful computers and sophisticated software, supported by TASK, for medical visualisation is emphasised. Some results of medical data and information visualisation obtained in our Department are presented.
  • R.Deklerck, A.Salomie, J.Cornelis, An Editor for 3D Medical Volume Images
    An editor for 3D medical images is presented. It allows to visualide anatomical atlases as well as modality images. Objects are delineated slice by slice as a stack of contours edited on the basis of Catmull-Rom splines. The design concepts and the implementation of the editing features are discussed.
  • M.Kocikowski, A.Polinski, A.Nowakowski, J.Wtorek, Problems of 3D reconstruction and visualisation in EIT
    In the paper different algorithms of electroimpedance tomography (EIT) are presented. The properties of EIT are discussed. Problems of proper modelling of measurement electrodes are introduced. Results obtained from developed 3D reconstruction algorithm are presented. For practical reasons the number of measurement electrodes should be increased. Measurement errors should be small, to avoid amplifying them by reconstruction algorithm. Assumed conductivity distribution for the first iteration should be as close to the real one as possible. Reconstruction time (of absolute value of conductivity) is still a problem for practical applications.
  • D.Kozinska , K.Nowinski, A.Kolodziejak, Integration of individual brain EEG and MRI information
    Accurate spacial localization of areas of pathological activity in the brain cortex is of great importance for studying processes of generation and propagation of electrical signals in the brain both in research and in clinic. This paper presents a method providing superposition of data aquired in EEG or EP examination with a patientís cortical surface computed from MR images. To integrate electrophysiological information with MRI-scanned anatomy scalp electrodes are registered with the cortex surface using distance based alignment technique. This approach is automatic and does not require any external fiducial markers to be fixed on a patientís head. It uses geometrical features derived from intrinsic image data to guide the alignment. That is why the method easy to apply to numerous examinations in clinic. Once data are registered, they are fused and rendered in 3D space as colour surface maps. The usefulness of the method for neurological assessment is demonstrated by presenting results of EEG and SEP studies performed on two patients.
  • R.J.Barczynski, A.Wawrenczuk, A.Kubasik, Nonlinear Methods in Heart Rate Variability
    In recent years, analysis of heart rate variability (HRV) has become common tool for the prediction of cardiac mortality. The universal rule is that a reduced variability is a signature for enhanced risk. However, the clinical value of the usual methods (the calculation of averages, standard deviations and variances of RR interval subsets, analysis of the power spectra in frequency domain) is very limited: false positive results cut the positive predictive value down to about 30%. We applied a few methods of determination of complexity in deterministic chaos (commonly associated with nonlinear dynamics) to 24 hour recordings of beat-to-beat heart-rate. It is likely that analysis of HRV by the means of nonlinear dynamics may open a way for a new classification of ventricular arrhythmias.
  • R.Kalicka, Optimal Multicompartmental Experiment Design
    Compartmental modelling of biomedical systems, devoted to e.g. optimal therapy design, provides us with a compartmental system, the associated set of differential equations, and a number of unknown parameters. We estimate values of the unknown parameters so that we obtain a best fit of the model input-output behaviour to the experimental data. If  the fit is not satisfactory, we remodel the structure of the system or/and reorganise the experiment design, and re-estimate the parameters. This is an iterative process, leading to the best model structure described with the most accurate values of its parameters. For satisfactory solution of the problem of optimal experiment design three co-operating computer programs are designed: MFIT, OSSP and OIN. MFIT enables to choose the best from any reasonable model functions. Reduced  optimal sampling schedule (OSSP) and optimal input signal (OIN) allow to get the most accurate parametersí value. They operate on the basis of output files of  MFIT. The final optimal experiment design is obtained by repeating the procedures.
  • R. Pawlowski, Population Genetics of the Amplified Fragment Length Polymorphism (AMPFL) and STR Type Systems in the Population of Northern Poland (Gdañsk Area)
    Paper presents results of the population studies of the VNTR polymorphic systems of human DNA. DNA samples were taken from at least 106 unrelated persons living in the Gdañsk area. DNA samples were subjected to the PCR amplification  and PCR products separated on polyacrylamide gels. Allelic frequencies of three AMPFLPs systems and six STRs were calculated and homogeneity of alleles distribution between Gdañsk and other population samples was compared using G-statistics computer programme.
  • J.Furmañski, R.Szczech, L.Znaniecki, M.Wroczynski, Brief Guide to Medical Internet
    Internet is a modern means of communication with a potentially great power of handling information. Nowadays, internet plays a crucial role in both medicine and health prevention.
    Internet services prepared by medical journals and publishers play a vital role in postgraduate education of medical professionals. Huge databases like Medline or Cancerlite are the most powerful tool for obtaining data on publications for the majority of doctors at academic centers. Internet is used for medical education of the community and the prevention of common and avoidable diseases, such as hypertension or diabetes mellitus, in which such education may decrease the risk of falling ill and developing complications.
    In the paper some medical internet addresses are listed and characterized.